Role of β-amyloid protein in hypoxic/ischemic brain injury
10.3760/cma.j.cn.115807-20220315-00061
- VernacularTitle:β淀粉样蛋白在缺氧/缺血性脑损伤中的作用研究
- Author:
Wei LIU
1
;
Jingjing ZHAO
;
Di ZHANG
;
Xuyi XIU
;
Lihua LI
Author Information
1. 首都医科大学附属北京潞河医院儿童中心，北京 101100
- Keywords:
β-amyloid;
Hypoxia;
Ischemia;
Brain injury
- From:
Chinese Journal of Endocrine Surgery
2022;16(3):375-377
- CountryChina
- Language:Chinese
-
Abstract:
β-amyloid protein (Aβ) is produced from β-amyloid precursor protein under the action of β-secretase and γ-secretase. Aβ accumulates and aggregates, forms oligomers and fibrils, and deposits in the brain, leading to functional neuronal death and cognitive impairment. β- amyloid protein induces inflammatory response, oxidative stress, free radical damage, calciumion disorder and so on, resulting in neuronal necrosis and apoptosis. Recent studies show that β-amyloid also plays an important role in hypoxia/ischemic brain injury. We review the mechanism of β-amyloid protein in hypoxic/ischemic brain injury.
