Correlations between different pH values in tumor microenvironment and bladder cancer
10.3760/cma.j.cn371439-20220507-00137
- VernacularTitle:肿瘤微环境pH值差异与膀胱癌的相关性
- Author:
Xi XU
1
;
Hongliang GAO
;
Xiang LIU
;
Zhensheng ZHANG
;
Chuanliang XU
Author Information
1. 海军军医大学附属长海医院泌尿外科，上海 200433
- Keywords:
Urinary bladder neoplasms;
pH;
Tumor microenvironment;
Therapy;
Prognosis
- From:
Journal of International Oncology
2022;49(11):696-699
- CountryChina
- Language:Chinese
-
Abstract:
Compared with normal tissue, interstitial extracellular pH of tumor cells is acidic. The reverse transmembrane pH gradient around tumor cells is closely related to its uncontrolled progression, angiogenesis and metastasis. Changes in urinary pH have an impact on the occurrence, progression and treatment of bladder cancer by regulating the microenvironment of bladder cancer cells. Relevant studies have shown that urinary pH value is an important factor in predicting the final clinical efficacy of bladder cancer patients combined with alkalization agents, which helps to reflect the acid-base balance and immune defense system in the body. Continuous monitoring of urinary pH can provide guidance and decision-making for the prognosis of bladder cancer patients.
