Biological indexes for predicting sensitivity of preoperative concurrent chemoradiotherapy for locally advanced rectal cancer
10.3760/cma.j.cn371439-20220429-00110
- VernacularTitle:预测局部晚期直肠癌术前同步放化疗敏感性的生物学指标
- Author:
Zhilei LI
1
;
Jialin LUO
Author Information
1. 中国科学院大学附属肿瘤医院（浙江省肿瘤医院）腹部放疗科，中国科学院基础医学与肿瘤研究所，杭州 310005
- Keywords:
Rectal neoplasms;
Chemoradiotherapy;
Sensitivity and specificity
- From:
Journal of International Oncology
2022;49(9):564-567
- CountryChina
- Language:Chinese
-
Abstract:
After the preoperative concurrent chemoradiotherapy for local advanced rectal cancer, the down-staging of tumor is obvious, the rate of anal preservation and the local control rate are improved, and the side reactions are acceptable, but the individual clinical efficacy varies greatly. Recent studies have found that cyclooxygenase-2, G protein coupled receptor, P53 binding protein 1, fibrinogen-to-albumin ratio, programmed cell death factor 4, tumor infiltrating lymphocytes, microRNA are related to the sensitivity of neoadjuvant therapy for locally advanced rectal cancer, which can predict the sensitivity of preoperative concurrent chemoradiotherapy.
