Research progress on the mechanism of CDK4/6 inhibitors promoting antitumor immunity by regulating the immune microenvironment of triple negative breast cancer
10.3760/cma.j.cn371439-20211215-00069
- VernacularTitle:CDK4/6抑制剂通过调控三阴性乳腺癌免疫微环境促进抗肿瘤免疫的机制研究进展
- Author:
Jiayi WU
1
;
Keyu CHEN
;
Xiying SHAO
;
Xiaojia WANG
Author Information
1. 浙江中医药大学第二临床医学院，杭州 310053
- Keywords:
Triple negative breast neoplasms;
Tumor microenvironment;
Cell cycle;
Immunocheckpoint inhibitors
- From:
Journal of International Oncology
2022;49(6):362-365
- CountryChina
- Language:Chinese
-
Abstract:
Triple negative breast cancer is a subtype of breast cancer with poor prognosis and lack of effective treatment. Cyclin dependent kinase (CDK) 4/6 inhibitors promote antitumor immunity by influencing the triple negative breast cancer immune microenvironment, such as increasing the tumor cell surface pragrammed death-ligand 1 protein expression, enhancing T cell activation and antigen presentation, changing the proportion of T cell subgroup and inducing lymphocyte infiltration. The change of immune microenvironment is related to tumor progression, but its mechanism is extremely complex. Exploring the mechanism of CDK4/6 inhibitor affecting immune microenvironment and its biomarkers can provide a new direction for the diagnosis and treatment of triple negative breast cancer.
