Research progress of oxidative stress in the sensitivity of chemoradiotherapy for gliomas
10.3760/cma.j.cn371439-20220309-00068
- VernacularTitle:氧化应激在胶质瘤放化疗敏感性中的研究进展
- Author:
Nan XIAO
1
;
Pengfei SUN
Author Information
1. 兰州大学第二临床医学院，兰州 730030
- Keywords:
Glioma;
Oxidative stress;
Chemoradiotherapy;
Radiation tolerance;
Reactive oxygen species
- From:
Journal of International Oncology
2022;49(6):357-361
- CountryChina
- Language:Chinese
-
Abstract:
Following oxidative stress, reactive oxygen species are produced and accumulate in glioma cells in large quantities, and to avoid the occurrence of cellular dysfunction, glioma cells can respond adaptively in the biological processes of DNA damage repair, lipid peroxidation and protein modification to produce radiotherapy resistance. The expression of nuclear factor erythroid 2-related factor 2, solute carrier family 7 member 11, glutathione and microRNA, as key regulatory molecules, can regulate reactive oxygen species levels, alter glioma oxidative stress status, and affect radiochemotherapy sensitivity. Further study on the relationship between oxidative stress and sensitivity to radiotherapy and chemotherapy of glioma can provide theoretical basis for precise treatment of glioma.
