Research progress in integrated diagnosis and treatment platform based on magnetic nanoparticles
10.3760/cma.j.cn121382-20210922-00116
- VernacularTitle:基于磁性纳米颗粒构建诊疗一体化平台的研究进展
- Author:
Junqi ZHAO
1
;
Yang LIU
;
Zhi DING
Author Information
1. 南京大学生命科学学院，南京 210023
- Keywords:
Magnetic nanoparticle;
Theranotics;
Drug-targeting;
Magnetothermal therapy;
Multimode imaging
- From:
International Journal of Biomedical Engineering
2022;45(1):73-79,85
- CountryChina
- Language:Chinese
-
Abstract:
Theranotics, an integrated diagnosis and treatment nanoplatform technology based on nanomaterials, integrates the diagnosis and treatment of diseases seamlessly and shows a broad prospect in medical practice. With the rapid development of nanomedicine, the technology of magnetic nanoparticles (MNPs) synthesis is becoming more and more mature. MNPs have controllable shape and particle size, admirable stability and biocompatibility, excellent magnetic properties, and can be readily chemically modified. These advantages make them widely used in clinical practice, such as diagnosis, targeted drug delivery, medical imaging, hyperthermia therapy, and radiotherapy, which also make MNPs high-quality materials for integrated diagnosis and treatment platforms.In this paper, the research progress of MNPs in the areas of magnetically guided drug delivery, magnetic thermotherapy, and multimodal imaging was reviewed; their advantages as an integrated platform for diagnosis and treatment were discussed; and the problems faced in research and application prospects were summarized and outlooked.
