Biomarkers of cognitive impairment in patients with cerebral small vessel disease
10.3760/cma.j.issn.1673-4165.2022.05.011
- VernacularTitle:脑小血管病患者认知损害的生物标志物
- Author:
Yunyun SHAO
1
;
Xue ZHENG
;
Bing FU
Author Information
1. 蚌埠医学院附属连云港市第二人民医院神经内科，连云港 222023
- Keywords:
Cerebral small vessel diseases;
Cognition disorders;
Biomarkers
- From:
International Journal of Cerebrovascular Diseases
2022;30(5):375-379
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral small vessel disease (CSVD) is the main cause of vascular cognitive impairment. Its mechanism is not yet fully clear, which may be associated with vascular endothelial dysfunction and the destruction of blood-brain barrier. In recent years, some studies have been conducted on biomarkers of cognitive impairment in patients with CSVD. This article reviews the biomarkers of cognitive impairment in patients with CSVD from the aspects of inflammatory response, oxidative stress, vascular endothelial dysfunction, endocrine, nervous system damage, and microRNAs.
