Update on epidemiology, treatment and genetics of purulent meningitis in children
10.3760/cma.j.issn.1673-4408.2022.08.004
- VernacularTitle:儿童化脓性脑膜炎流行病学、治疗及遗传学研究进展
- Author:
Lingyu ZHANG
1
;
Yue HU
Author Information
1. 重庆医科大学附属儿童医院神经内科 国家儿童健康与疾病临床医学研究中心 儿童发育疾病研究教育部重点实验室 儿科学重庆市重点实验室 400010
- Keywords:
Children;
Purulent meningitis;
Epidemiology;
Genetics;
Treatment
- From:
International Journal of Pediatrics
2022;49(8):519-523
- CountryChina
- Language:Chinese
-
Abstract:
Purulent meningitis(PM)is the main reasons of infectious diseases in the central nervous system of children.It is one of the leading causes of neurological sequelae in children.Pathogens are related to region, socioeconomic status, environment, age, etc.The epidemiology has been changing owing to the increasing vaccination coverage rate.Streptococcus pneumoniae, Staphylococcus epidermidis, Escherichia coli and group B Streptococcus are the main pathogens of PM in children.Antibiotics are the main treatment.Corticosteroids are controversial in the treatment of PM.Vaccination is the main method to prevent PM and its complications.With the development of genetics, the genetic variation of immune system has been proved to be related to the susceptibility of PM.This article reviews recent advances in epidemiological changes, treatment, and genetic associations of PM in children.It is helpful for the diagnosis and treatment of PM.
