Progress on T cell subsets and pathogenesis of asthma
10.3760/cma.j.issn.1673-4408.2022.08.002
- VernacularTitle:T细胞亚群与哮喘发病机制的研究进展
- Author:
Xiaoqian WANG
1
;
Xiao HAN
;
Xiaobo ZHANG
;
Libo WANG
Author Information
1. 复旦大学附属儿科医院呼吸科，上海 201102
- Keywords:
Asthma;
T cell;
Pathogenesis;
Immunity;
Cytokine
- From:
International Journal of Pediatrics
2022;49(8):510-514
- CountryChina
- Language:Chinese
-
Abstract:
Asthma is a common chronic airway inflammatory disease, which is characterized by airway stenosis, airway wall thickening and increased mucus secretion followed by reversible airflow restriction.At present, asthma is considered to be a complex and heterogeneous disease, and its pathogenesis remains elusive.There are diverse immune cells involved in the formation of asthma, including T lymphocytes, eosinophils, neutrophils, etc.Due to the continuous renewal of classification and function of T lymphocytes subsets, their role in asthma has attracted more attention.Here, this review aims to summarize the immunological characteristics and roles of different T cell subsets in asthma, and highlight the new findings of T cell subsets in the pathogenesis of severe asthma, leading to provide inspiration and help for the study of the immunology pathogenesis, clinical diagnosis, treatment and prognosis in asthma.
