Studies on orally disintegrating tablet of diphenhydramine hydrochloride and caffeine
10.12206/j.issn.2097-2024.202108090
- VernacularTitle:盐酸苯海拉明咖啡因口崩片的研究
- Author:
Li FAN
1
;
Yuan ZENG
2
;
Xiangyang XIE
2
;
Hui LIU
2
;
Jing XIONG
3
;
Ying ZHANG
3
;
Yuan YUAN
4
Author Information
1. Department of Pharmaceutics, School of Pharmacy, Naval Medical University, Shanghai 200433, China.
2. Medical Security Center, the General Hospital of Central Theater Command of the PLA, Wuhan 430070, China.
3. Medical Security Center, the General Hospital of Central Theater Command of the PLA, Wuhan 430070, China;College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China.
4. Drug Supply Station of Medical Support Center, No. 905 Hospital of Naval Medical Univeresity, Shanghai 200052, China.
- Keywords:
orally disintegrating tablet;
diphenhydramine hydrochloride;
caffeine
- From:
Journal of Pharmaceutical Practice
2023;41(1):45-49
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the formulation and preparation of diphenhydramine hydrochloride and caffeine orally disintegrating tablet. Methods Melt granulation technology of steric acid and API was used to mask the unpleasant tasting of diphenhydramine hydrochloride. The tablets were prepared by direct pressing the dry powder with CCMC-Na as disintegrating agent. The formulation was optimized by orthogonal experiments to achieve the shortest disintegration time and the best taste correction. Results The optimized formula of orally disintegrating tablet was as follows： diphenhydramine hydrochloride 25 mg, caffeine 60 mg, stearic acid 25 mg, aspatan 40 mg, blueberry essence 7 mg, mannitol 45 mg, MCC 210 mg, CCMC-NA 25 mg, SDS 8 mg and magnesium stearate 5 mg. Conclusion This preparation method for orally disintegrating tablet of diphenhydramine hydrochloride and caffeine is practical and easy for quality control.
