Dissolution behavior of aripiprazole tablets based on near infrared spectroscopy
10.12206/j.issn.2097-2024.202108066
- VernacularTitle:基于近红外光谱的阿立哌唑片溶出行为研究
- Author:
Weiqing WANG
1
;
Wen YANG
2
;
Feng LU
2
Author Information
1. School of Pharmacy, Naval Medical University, Shanghai 200433, China;School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 117004, China;Key Laboratory for Quality Analysis of Chemical Drug Preparations of NMPA, Shanghai 201203, China.
2. School of Pharmacy, Naval Medical University, Shanghai 200433, China.
- Keywords:
near infrared spectroscopy;
aripiprazole tablets;
dissolution
- From:
Journal of Pharmaceutical Practice
2023;41(1):36-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a near infrared (NIR) quantitative model for the dissolution behavior of aripiprazole tablets. Methods The NIR spectra of aripiprazole tablets were collected and the dissolution tests were performed to determine the dissolution of each tablet at 3, 6, 9, 12, 15 and 30 min. The near infrared spectra regions of 4 000.00-4 396.90, 5 326.43-12 000.00 cm−1 were pretreated by Savitzky-Golay smoothing filter, and the dissolution behavior model was established by partial least squares method. Results The root mean square error of calibration (RMSEC) and the root mean square error of prediction (RMSEP) at different time points were analyzed. RMSEP was lower than 8%. The calibration correlation coefficient (RC) and the prediction correlation coefficient (RP) at different time points were above 0.95 (except for the point of 6 min). There was a good correlation between the NIR spectrum and the dissolution at each time point. Conclusion NIR spectroscopy could predict the dissolution behavior of aripiprazole tablets, which lays a foundation for online quality monitoring of tablets by NIR spectroscopy.
