Neuroprotective effects of kukoamine A on 6-OHDA-induced Parkinson's model through apoptosis and iron accumulation inhibition

Author: Xin LI ¹ ; Xiao-wen JIANG ¹ ; Hai-xiao CHU ¹ ; Qing-chun ZHAO ¹ ; Chao-hong CAI ¹ ; Huai-wei DING ² ; Xiao-wen JIANG ³
Author Information

1. Department of Pharmacy, General Hospital of Northern Theater Command
2. Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University
3. Department of Traditional Chinese Medicine, Shenyang Pharmaceutical University
Publication Type:Journal Article
Keywords: 6-OHDA; iron chelation; iron homeostasis; kukoamine A; neuroprotection; Parkinson's disease
From: Chinese Herbal Medicines 2021;13(1):105-115
CountryChina
Language:Chinese
Abstract: Objective: Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in substantia nigra (SN). Our previous study demonstrated kukoamine A (KuA) to exhibit strong neuroprotective effects through antioxidative stress, and autophagy in MPTP/MPP