Prognosis of adenoid cystic carcinoma of head and neck and risk factors for lung metastasis.
10.3760/cma.j.cn115330-20220508-00256
- VernacularTitle:头颈部腺样囊性癌治疗预后及肺转移危险因素分析
- Author:
Xue Lian WANG
1
;
Meng Jiao ZHOU
1
;
Ting Yao MA
1
;
Ling Yan JIANG
2
;
Qi Dong ZHAO
1
;
Hong Bo XU
1
;
Jing ZHOU
1
;
Li Feng LI
1
;
Lu KONG
3
;
Xiaohong CHEN
1
Author Information
1. Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing 100730, China.
2. Department of Otolaryngology, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, China.
3. Department of Biochemistry and Molecular Biology, School of Basic Medicine, Capital Medical University, Beijing 100069, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Carcinoma, Adenoid Cystic;
Female;
Humans;
Lung/pathology*;
Lung Neoplasms/secondary*;
Male;
Middle Aged;
Prognosis;
Retrospective Studies;
Risk Factors;
Young Adult
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2022;57(8):963-968
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze the prognosis and risk factors of lung metastasis of patients with adenoid cystic carcinoma(ACC) of head and neck. Methods: A retrospective study was conducted. The data of 157 patients with ACC of head and neck treated in Beijing Tongren Hospital, Capital Medical University from January 2014 to October 2020 were collected, including 72 males and 85 females, with onset age between 14 and 72 years old. According to whether lung metastasis occurred, the patients were divided into lung metastasis group (88 cases) and non-pulmonary metastasis group (69 cases). Kaplan-Meier method was used to calculate the overall survival rate and progression-free survival rate using SPSS 26.0 software. Log-rank test was used to evaluate statistically relevant clinicopathological factors. Cox proportional risk model was used in multivariate analysis for the factors affecting the lung metastasis-free survival using R Studio 1.2.5042. Results: The 3-year and 5-year overall survival rates were 91.5% and 85.2%, respectively. The 3-year and 5-year progression-free survival rates were 57.7% and 34.3%, respectively. Univariate analysis showed that primary site, histological grade, high-grade transformation, Ki-67, T stage, and lymph node status were the risk factors for lung metastasis (χ2=11.78, 10.41, 4.06, 4.71, 5.37, 16.20, respectively, all P<0.05). Multivariate analysis showed independent risk factors for lung metastasis, including submandibular gland and sublingual gland (HR=3.53, 95%CI: 1.19-10.46, P<0.05), T3-4 stage (HR=3.09, 95%CI: 1.54-6.23, P<0.05), and Grade Ⅱ-Ⅲ grade (HR=2.47, 95%CI: 1.26-4.86,P<0.05). Conclusion: Distant metastasis, mainly pulmonary metastasis, affects the long-term prognosis of patients with ACC significantly. Primary site, T stage and histopathological grade can be used as the predictors for the risk of lung metastasis.
