Risk factors and chemoprophylaxis of ulcerative colitis-colorectal cancer.
10.3760/cma.j.cn112150-20220411-00344
- VernacularTitle:溃疡性结肠炎相关性结直肠癌的危险因素及化学预防
- Author:
Shu PANG
1
;
Ye ZONG
2
;
Yong Dong WU
2
Author Information
1. Department of General Practice, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
2. Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050,China.
- Publication Type:Journal Article
- MeSH:
Humans;
Colitis, Ulcerative/diagnosis*;
Colorectal Neoplasms/diagnosis*;
Risk Factors;
Chemoprevention/adverse effects*;
Carcinogenesis
- From:
Chinese Journal of Preventive Medicine
2022;56(11):1657-1662
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis-colorectal cancer (UC-CRC) is one of the most serious complications in patients with ulcerative colitis (UC), with worse prognosis and higher mortality than sporadic colorectal cancer (CRC). Since most UC-CRC developed through the "inflammation-dysplasia-carcinoma" approach, early detection of dysplasia through identification of high-risk groups reasonable monitoring and active prevention are extremely important. However, there is no consensus on the risk factors of UC carcinogenesis and the drugs that can be used for chemoprevention currently. This article combined with relevant literature at home and abroad, reviewed the current risk factors and chemopreventive drugs for UC carcinogenesis, in order to provide reference for early prevention, early detection and early diagnosis of UC-CRC.
