The clinical characteristics and treatment of children with disorders of sex development and early prevention of their siblings.
10.3760/cma.j.cn112150-20220528-00540
- VernacularTitle:儿童性发育异常疾病的临床特征与治疗及其同胞的早期预防
- Author:
Sha Sha ZHOU
1
;
Pin LI
1
Author Information
1. Department of Endocrinology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200062,China.
- Publication Type:Journal Article
- MeSH:
Disorders of Sex Development/prevention & control*;
Female;
Hormones;
Humans;
Pregnancy;
Siblings
- From:
Chinese Journal of Preventive Medicine
2022;56(9):1203-1210
- CountryChina
- Language:Chinese
-
Abstract:
Disorders of sex development (DSD) is a class of diseases characterized by discordant phenotypes of sex chromosome karyotypes, gonads and external genitalia. The etiology is complex and the clinical manifestations are varied. Understanding the clinical characteristics of patients with various types of DSD help make accurate etiological diagnosis and prepare individualized treatment plans according to the etiology (including sex assignment, endocrine hormone replacement, surgery and fertility protection, etc.). Due to the increased risk of DSD in the second pregnancy of the parents of DSD patients, early preventive measures such as pre-pregnancy genetic counseling and prenatal diagnosis during pregnancy can effectively avoid or reduce the risk of DSD in their siblings.
