CXCL10/CXCR3 Signaling in the DRG Exacerbates Neuropathic Pain in Mice

Author: Yan-Fang KONG ¹ ; Wei-Lin SHA ¹ ; Xiao-Bo WU ¹ ; Lin-Xia ZHAO ¹ ; Ling-Jie MA ¹ ; Yong-Jing GAO ¹ ; Yong-Jing GAO ²
Author Information

1. Institute of Pain Medicine, Institute of Nautical Medicine, Nantong University
2. Co-Innovation Center of Neuroregeneration, Nantong University
Publication Type:Journal Article
Keywords: CXCL10; CXCR3; DRG; Mice; Neuropathic pain
From: Neuroscience Bulletin 2021;37(3):339-352
CountryChina
Language:Chinese
Abstract: Chemokines and receptors have been implicated in the pathogenesis of chronic pain. Here, we report that spinal nerve ligation (SNL) increased CXCR3 expression in dorsal root ganglion (DRG) neurons, and intra-DRG injection of Cxcr3 shRNA attenuated the SNL-induced mechanical allodynia and heat hyperalgesia. SNL also increased the mRNA levels of CXCL9, CXCL10, and CXCL11, whereas only CXCL10 increased the number of action potentials (APs) in DRG neurons. Furthermore, in Cxcr3