TLR8 in the Trigeminal Ganglion Contributes to the Maintenance of Trigeminal Neuropathic Pain in Mice
- Author:
Lin-Xia ZHAO
1
;
Xue-Qiang BAI
1
;
Tong-Tong CHEN
1
;
Juan WANG
1
;
Zhi-Jun ZHANG
1
;
Lin-Xia ZHAO
2
;
Ming JIANG
2
;
De-Li CAO
2
;
Xiao-Bo WU
2
;
Jing ZHANG
2
;
Jian-Shuang GUO
2
;
Yong-Jing GAO
2
;
Zhi-Jun ZHANG
2
;
Hao WU
3
;
Yong-Jing GAO
4
Author Information
- Publication Type:Journal Article
- Keywords: ERK; Mouse; p38; Pro-inflammatory cytokine; TLR8; Trigeminal ganglion; Trigeminal neuropathic pain
- From: Neuroscience Bulletin 2021;37(4):550-562
- CountryChina
- Language:Chinese
- Abstract: Trigeminal neuropathic pain (TNP) is a significant health problem but the involved mechanism has not been completely elucidated. Toll-like receptors (TLRs) have recently been demonstrated to be expressed in the dorsal root ganglion and involved in chronic pain. Here, we show that TLR8 was persistently increased in the trigeminal ganglion (TG) neurons in model of TNP induced by partial infraorbital nerve ligation (pIONL). In addition, deletion or knockdown of Tlr8 in the TG attenuated pIONL-induced mechanical allodynia, reduced the activation of ERK and p38-MAPK, and decreased the expression of pro-inflammatory cytokines in the TG. Furthermore, intra-TG injection of the TLR8 agonist VTX-2337 induced pain hypersensitivity. VTX-2337 also increased the intracellular Ca
