Anti-proliferative and anti-angiogenic activities of ion-channel modulators: In-ovo, in-vitro and in-vivo study
10.1016/j.apjtb.2017.05.005
- Author:
Chandana KAMILI
1
;
Ravi Shankar KAKATAPARTHY
2
;
Uma Maheshwararao VATTIKUTTI
3
;
Vijay CHIDRAWAR
4
;
Sindhuri AMMINENI
5
Author Information
1. Department of Pharmacology, CMR College of Pharmacy, JNTUH
2. Department of Pharmacology, Sri Sai Aditya Institute of Pharmaceutical Sciences and Research
3. Department of Pharmacognosy, TRR College of Pharmacy
4. Department of Pharmacology and Toxicology, Northern Border University
5. Department of Pharmacology, CMR College of Pharmacy
- Publication Type:Journal Article
- Keywords:
Aortic ring assay;
Chick Chorioallantoic membrane;
Ion-channels;
Sponge implantation method
- From:Asian Pacific Journal of Tropical Biomedicine
2017;7(6):555-562
- CountryChina
- Language:Chinese
-
Abstract:
Objective Angiogenesis is the development of new blood vessels. The ion channels on endothelium play a vital action in cell proliferation and so in the related angiogenesis. We aimed to investigate the anti-angiogenic effects of Mefloquine (Cl− channel blocker) and 4-Aminopyridine (K+ channel blocker). Methods The anti-angiogenic activities of Mefloquine and 4-Aminopyridine (4-AP) were investigated by in-vivo (sponge implantation method), in-vitro (aortic ring assay) and in-ovo (CAM, Chick Chorioallantoic membrane) methods. The standard antiangiogenic drug used was Bevacizumab. Results In the CAM assay, both the ion channel blockers exhibited noticeable antiangiogenic activity at the concentrations of 10
