NO-cGMP-K channel-dependent anti-nociceptive activities of methanol stem bark extract of Piptadeniastrum africanum (Mimosaceae) on rats

Author: Mbiantcha MARIUS ¹ ; Ateufack GILBERT ¹ ; Bomba Tatsinkou Francis DESIRE ¹ ; Almas JABEEN ² ; Nida DASTAGIR ² ; Shabana U. SIMJEE ³
Author Information

1. Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, University of Dschang
2. Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi
3. H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi
Publication Type:Journal Article
Keywords: cGMP; Inflammatory pain; Neuropathic pain; Nitric oxide; Piptadeniastrum africanum
From:Asian Pacific Journal of Tropical Biomedicine 2018;8(3):150-159
CountryChina
Language:Chinese
Abstract: Objective: To explore anti-hyperalgesic properties of methanol extract of Piptadeniastrum africanum stem bark (PAME) and it possible action mechanism. Methods: PAME was tested on carrageenan induced hyperalgesia using plantar test (thermal) and analgesymeter (mechanical) in rats, on prostaglandin E