Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis.

Author: Li YANG ¹ ; Jin CHEN ¹ ; Jianqing LIANG ¹ ; Yufeng ZHANG ¹ ; Qingzhe WANG ² ; Xiaojun REN ³ ; Jinsong WEI ¹ ; Qianchun GONG ¹ ; Jiting ZHANG ¹ ; Ning JIANG ¹ ; Xinhua LIN ¹ ; Jin LI ⁴ ; Bing ZHAO ⁵
Author Information

1. State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, 200438, China.
2. bioGenous Biotechnology, Inc., Hangzhou, 311231, China.
3. Obstetrics and Gynecology Hospital of Fudan University, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Fudan University, Shanghai, 200011, China.
4. State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, 200438, China. Li_Jin_lifescience@fudan.edu.cn.
5. State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, 200438, China. bingzhao@fudan.edu.cn.
Publication Type:Research Support, Non-U.S. Gov't
MeSH: Carcinogenesis; Cell Transformation, Neoplastic; Hepatoblastoma; Humans; Liver; Liver Neoplasms; Organoids; YAP-Signaling Proteins
From: Protein & Cell 2022;13(9):683-688
CountryChina
Language:English