Hyperthyroidism after Allogeneic Hematopoietic Stem Cell Transplantation.
10.19746/j.cnki.issn.1009-2137.2022.04.043
- Author:
Xiao-Li ZHENG
1
;
Hong-Min YAN
1
;
Li XIAO
2
;
Dong-Mei HAN
1
;
Li DING
1
;
Mei XUE
1
;
Ling ZHU
1
;
Jing LIU
1
;
Da ZHANG
2
;
Heng-Xiang WAN
3
Author Information
1. Department of Hematology, Air Force Medical Center, PLA, Beijing 100142, China.
2. Department of Endocrinology, Air Force Medical Center, PLA, Beijing 100142, China.
3. Department of Hematology, Air Force Medical Center, PLA, Beijing 100142, China,E-mail: wanghengxiang123@aliyun.com.
- Publication Type:Journal Article
- Keywords:
graft versus host disease;
hematopoietic stem cell transplantation;
hyperthyroidism
- MeSH:
Adult;
Child;
Female;
Graft vs Host Disease;
Hematopoietic Stem Cell Transplantation/adverse effects*;
Humans;
Hyperthyroidism/complications*;
Hypothyroidism/complications*;
Male;
Quality of Life;
Retrospective Studies;
Thyroxine/therapeutic use*;
Transplantation Conditioning/adverse effects*
- From:
Journal of Experimental Hematology
2022;30(4):1244-1247
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the clinical characteristics, etiology, therapy and outcome of hyperthyroidism after allogeneic hematopoietic stem cell transplantation (HSCT).
METHODS:The clinical data of 7 patients who experienced hyperthyroidism were retrospectively analyzed in our hospital.
RESULTS:These 7 patients (5 males, 2 females) suffered hyperthyroidism after HSCT. All patients did not apply the pretreatment regimen containing total body irradiation (TBI). The median age was 25 years old, only one child. Six patients underwent haploidentical HSCT except one patient after unrelated HSCT. The median time of hyperthyroidism occurrence was 20 months. Two patients experienced chronic graft versus host disease (GVHD) when hyperthyroidism occurred and were treated successfully with glucocorticoid, however one patient suffered hypothyroidism 3 months later and needed long-term oral levothyroxine maintenance. One patient developed hypothyroidism post treatment of 131I. The other four patients were treated with methimazole and all of them showed normal thyroid function except one patient suffered from hypothyroidism 1 year later and needed long-term oral levothyroxine maintenance.
CONCLUSION:Hyperthyroidism is a rare complication after HSCT but may affect healthy and lead to lower quality of life. Routine thyroid function monitoring should be recommended after HSCT. Treatment of hyperthyroidism should be given according to the pathogeny.
