Risk factors for food sensitization in children with atopic dermatitis: a single-center cross-sectional study.
10.7499/j.issn.1008-8830.2202098
- Author:
Dan WANG
1
;
Xue-Ge WU
1
;
Shi YAN
1
;
Tian-Tian ZHOU
1
;
Ya-Jiao HUANG
1
;
Jie LI
1
;
Xiao-Yan LUO
1
Author Information
1. Department of Dermatology, Children's Hospital of Chongqing Medical University/National Clinical Research Center for Child Health and Disorders/Ministry of Education Key Laboratory of Child Development and Disorders/Chongqing Key Laboratory of Child Infection and Immunity, Chongqing 401122, China.
- Publication Type:Journal Article
- Keywords:
Atopic dermatitis;
Child;
Clinical sign;
Food sensitization;
Quality of life;
Risk factor
- MeSH:
Allergens;
Child;
Cross-Sectional Studies;
Dermatitis, Atopic;
Food Hypersensitivity;
Humans;
Immunoglobulin E;
Infant;
Quality of Life;
Retrospective Studies;
Risk Factors
- From:
Chinese Journal of Contemporary Pediatrics
2022;24(8):887-893
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To study the risk factors for food sensitization and the influence of food sensitization on quality of life and clinical signs in children with atopic dermatitis (AD).
METHODS:A retrospective analysis was performed on the medical data of 241 children with AD, including demographic features, age of onset, severity of AD, quality of life, physical examination results, skin prick test (SPT) results, serum total IgE levels, and eosinophil count. According to the results of SPT, the children were divided into a food sensitization group (n=127) and a non-food sensitization group (n=114). The multivariate logistic regression analysis was used to identify the risk factors for food sensitization in children with AD.
RESULTS:The prevalence rate of food sensitization was 52.7% (127/241) in the children with AD. The multivariate logistic regression analysis showed that birth in autumn or winter, age of onset of AD<12 months, severe AD, and total IgE>150 IU/mL were risk factors for food sensitization (P<0.05). Compared with the non-food sensitization group, the food sensitization group had a significantly poorer quality of life (P=0.008) and significantly higher prevalence rates of non-specific hand/foot dermatitis and palmar hyperlinearity (P<0.05). Compared with the single food sensitization group, the multiple food sensitization group had more severe AD and a significantly higher proportion of children with exclusive breastfeeding or total IgE>150 IU/mL (P<0.05).
CONCLUSIONS:The AD children born in autumn or winter, or those with early onset (<12 months), severe AD or total IgE>150 IU/mL have a higher risk of food sensitization. The AD children with food sensitization have a poorer quality of life and are more likely to develop non-specific hand/foot dermatitis and palmar hyperlinearity.
