Modern research on Chinese medicine based on single-cell omics: technologies and strategies.
10.19540/j.cnki.cjcmm.20220601.702
- Author:
Peng-Hui YANG
1
;
Li-Jun JIN
1
;
Jie LIAO
1
;
Xin SHAO
1
;
Jun-Yun CHENG
1
;
Lu LI
1
;
Xiao-Yan LU
2
;
Xiao-Hui FAN
2
Author Information
1. Department of Chinese Medicine Science & Engineering, College of Pharmaceutical Sciences, Zhejiang University Hangzhou 310058, China.
2. Department of Chinese Medicine Science & Engineering, College of Pharmaceutical Sciences, Zhejiang University Hangzhou 310058, China Innovation Center in Zhejiang University, State Key Laboratory of Component-based Chinese Medicine Hangzhou 310058, China.
- Publication Type:Journal Article
- Keywords:
modernization of Chinese medicine;
single-cell multimodal omics;
single-cell omics;
spatial transcriptomics
- MeSH:
Drugs, Chinese Herbal/pharmacology*;
Medicine, Chinese Traditional;
Technology
- From:
China Journal of Chinese Materia Medica
2022;47(15):3977-3985
- CountryChina
- Language:Chinese
-
Abstract:
As one of the most advanced technologies, single-cell omics technology develops rapidly in recent years. Based on different technical strategies, it enables unbiased and high-throughput access to multiple omics information at single-cell resolution. So far, single-cell omics technology, by virtue of its great powder in resolving tissue heterogeneity, has become a revolutionary tool to deeply understand the functional structure of tissues, reveal complex disease processes, and elucidate drug mechanisms of action. In view of the technical challenges in deconstructing the complexity of Chinese medicine and clarifying the modern scientific connotation of traditional Chinese medicine(TCM) theory, single-cell omics technology has huge application potential in the discovery of pharmacodynamic substances, construction of action networks, and elucidation of integrated regulatory mechanisms, which brings new opportunities for modern research in TCM. The present study briefly introduced three representative single-cell omics technologies, i.e., single-cell transcriptome sequencing, spatial transcriptomics, and single-cell multimodal omics, and their main application patterns. On this basis, an outlook was proposed on the strategies and applications for modern research in TCM using single-cell omics technology.
