Research progress of Acanthopanax senticosus in prevention and treatment of neurodegenerative diseases.
10.19540/j.cnki.cjcmm.20220307.701
- Author:
Xue WANG
1
;
Zhao DAI
1
;
Jian-Song FANG
1
Author Information
1. Science and Technology Innovation Center of Guangzhou University of Chinese Medicine Guangzhou 510405, China.
- Publication Type:Journal Article
- Keywords:
Acanthopanax senticosus;
kidney-tonifying;
neurodegenerative diseases;
research progress
- MeSH:
Amyloid beta-Peptides;
Anti-Inflammatory Agents;
Eleutherococcus/chemistry*;
Epigenesis, Genetic;
Humans;
Neurodegenerative Diseases/prevention & control*;
Plant Extracts/therapeutic use*
- From:
China Journal of Chinese Materia Medica
2022;47(16):4314-4321
- CountryChina
- Language:Chinese
-
Abstract:
Neurodegenerative diseases are global public health problems that seriously affect the quality of human life. The incidence of neurodegenerative diseases is increasing year by year and there has been no effective treatment. Acanthopanax senticosus is a Chinese medicine for tonifying kidney and has a long medicinal and edible history. It contains many active ingredients such as saponins, coumarins, flavonoids, organic acids and polysaccharides, with pharmacological effects of anti-oxidation, anti-age, anti-inflammation, anti-fatigue and immune regulation. Modern medical studies have found that A. senticosus can act on the central nervous system, and its extracts and active ingredients can improve learning and memory ability, playing vital roles of anti-oxidation, anti-inflammation, anti-apoptosis, antagonizing against amyloid β protein(Aβ) toxicity, modulating neurotransmitter release, signaling pathways and brain energy metabolism, maintaining the structure and function of mitochondria, and epigenetic regulation. It treats neurodegenerative diseases via multiple components, multiple targets, and multiple pathways, with the characteristics of low toxic side effects. This study reviewed the pharmacological reports of A. senticosus on neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and ischemic stroke in China and abroad in recent ten years, and summarized the active ingredients and the mechanism underlying the neuroprotective effects of A. senticosus. Additionally, the significant advantages of A. senticosus in the treatment of neurodegenerative diseases and the limitations of the reports were discussed from the aspects of traditional Chinese medicine(TCM) theory and modern medical research. This study provided theoretical support for the drug development and clinical application of A. senticosus in treating neurodegenerative diseases and also facilitated the prevention and treatment of neurodegenerative diseases by kidney-tonifying method in TCM.
