Mechanism of Mesenchymal Stem Cells in the Treatment of Asthma.
10.3881/j.issn.1000-503X.14960
- Author:
Tao WANG
1
;
Jun WANG
2
Author Information
1. Department of Medicine,Nanchang University,Nanchang 330006,China.
2. Jiangxi Provincial People's Hospital (The First Affiliated Hospital of Nanchang Medical College),Nanchang 330006,China.
- Publication Type:Journal Article
- Keywords:
bronchial asthma;
mechanism of action;
mesenchymal stem cell
- MeSH:
Humans;
Animals;
Mesenchymal Stem Cell Transplantation;
Mesenchymal Stem Cells;
Asthma/therapy*;
Airway Remodeling;
Cell Differentiation;
Disease Models, Animal
- From:
Acta Academiae Medicinae Sinicae
2022;44(5):845-856
- CountryChina
- Language:Chinese
-
Abstract:
Asthma,a chronic inflammatory disease of respiratory system,is characterized by airway hyperresponsiveness,chronic airway inflammation,mucus secretion,and airway remodeling.Mesenchymal stem cell (MSC) are a kind of multifunctional stem cells,which have the ability of self-renewal and multi-directional differentiation.They are involved in a variety of physiological processes,such as immune response,antigen presentation,inflammatory response,and cell migration.MSCs plays a key role in the pathogenesis of bronchial asthma,while the underlying mechanism remains to be studied.MSC are a potential target for the treatment of bronchial asthma.This paper reviews the mechanism of MSC in the treatment of asthma.
