Recurrence Rate and Risk Factors of Atypical Meningioma:a Meta-analysis.
10.3881/j.issn.1000-503X.14435
- Author:
Guo-Qiang LI
1
;
Yu-Hong LUO
2
;
Yue YU
1
;
Yan-Long XU
1
;
Yi-Nian ZHANG
1
Author Information
1. Department of Neurosurgery,Lanzhou University Second Hospital,Lanzhou 730030,China.
2. Department of Nursing,the Affiliated Hospital of Guizhou Medical University,Guiyang 550000,China.
- Publication Type:Meta-Analysis
- Keywords:
atypical meningioma;
meta-analysis;
recurrence rate;
systematic evaluation;
tumor recurrence
- MeSH:
Female;
Humans;
Male;
Meningeal Neoplasms;
Meningioma;
Middle Aged;
Neoplasm Recurrence, Local;
Postoperative Period;
Risk Factors
- From:
Acta Academiae Medicinae Sinicae
2022;44(4):570-578
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically review the overall status of postoperative recurrence in patients with atypical meningiomas. Methods China National Knowledge Infrastructure,Wanfang Database,Chinese Biomedical Literature Database,VIP Database,PubMed,Embase,Web of Science,and Cochrane Library were searched for collection of the relevant literature on the recurrence of atypical meningioma from database establishment to July 2021.Two investigators independently screened the literature,extracted data,and assessed the risk of bias of the included studies,and then performed a meta-analysis by using R 5.0. Results A total of 29 studies involving 3122 patients were included in this study.The meta-analysis showed that the overall postoperative recurrence rate of atypical meningioma was 38%.The subgroup analysis showed that the tumor recurrence rate of patients ≥60 years old and<60 years old was 51% and 40%,respectively,with no significant difference.The tumor recurrence rates in male and female patients were 42% and 44%,respectively,which showed no significant difference.The recurrence rates of the patients with parasagittal meningiomas,brain tissue infiltration,Ki-67>8%,mitotic count ≥6/10 high-power fields,and tissue necrosis were 52%,47%,63%,53%,and 69%,respectively.The recurrence rate after subtotal tumor resection was as high as 58%,and the patients who received radiotherapy had higher tumor recurrence rate than that those who did not receive radiotherapy (38% vs.29%,P=0.007). Conclusions The current evidence demonstrates that atypical meningioma has a high recurrence rate after surgery.It is essential to pay more attention and take corresponding measures to improve the tumor-free survival rate of the patients.
