Effect of vitamin C and E on the lipid peroxide, antioxidant ability, and antioxidant vitamin levels in maternal and umbilical venous plasma.
- Author:
Yoon Ha KIM
1
;
Jong Woon KIM
;
Chul Hong KIM
;
Moon Kyoung CHO
;
Seok Mo KIM
;
Woo Dae KANG
;
Hye Yon CHO
;
Sung Yeul YANG
;
Bong Whan AHN
;
Tae Bok SONG
Author Information
1. Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju, Korea. kimyh@chonnam.ac.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Vitamin supplementation;
Total antioxidant ability;
Maternal venous plasma;
Umbilical venous plasma;
Lipid peroxide
- MeSH:
alpha-Tocopherol;
Ascorbic Acid;
beta Carotene;
Female;
Fetus;
gamma-Tocopherol;
Humans;
Membranes;
Plasma;
Pre-Eclampsia;
Pregnant Women;
Rupture;
Thiobarbiturates;
Uric Acid;
Vitamin A;
Vitamin E;
Vitamins
- From:Korean Journal of Obstetrics and Gynecology
2009;52(11):1117-1126
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: This controlled trial investigated the effect of supplementation with vitamins C and E on the lipid peroxide, antioxidant ability, and antioxidant vitamin levels in full term maternal and umbilical venous plasma. METHODS: Forty pregnant women were randomized in this study. They were nulliparous or multiparous women with history of preeclampsia or preterm premature rupture of membranes (PPROM). Twenty women were given vitamin C (1,000 mg/day) and vitamin E (400 IU/day) from 15~20 gestational weeks to delivery. The others were not given, as a control group. Maternal venous blood was obtained before vitamin supplementation and just before delivery. Umbilical venous blood was obtained after delivery. Lipid peroxide level and oxygen-radical absorbance capacity (ORAC) were measured by thiobarbituric acid reaction and Cao's method, respectively. Ascorbic acid, uric acid, beta-carotene, retinol, alpha-tocopherol, and gamma-tocopherol were measured by high performance liquid chromatography. Results: Supplementation with vitamins C and E was associated with decrease in lipid peroxide levels and increase in ORAC values and alpha-tocopherol levels in maternal venous plasma. And it was also associated with decrease in lipid peroxide levels and increase in ORAC values and alpha-tocopherol levels in umbilical venous plasma. CONCLUSION: Supplementation with vitamins C and E may be beneficial in the prevention of oxidant-antioxidant imbalance origin diseases such as preeclampsia, PPROM. And it also may affect antioxidant ability of the fetus.
