Anticancer effects of metformin in experimental animal models of different types of cancer: a systematic review and meta-analysis
10.1186/s42826-022-00131-6
- Author:
Fan ZHANG
1
;
Shuai HAN
;
Weijie SONG
Author Information
1. Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, People’s Republic of China
- Publication Type:SHORT COMMUNICATION
- From:Laboratory Animal Research
2022;38(3):239-246
- CountryRepublic of Korea
- Language:English
-
Abstract:
To systematically evaluate the effects of metformin on tumors in experimental animal models of different types of cancer. Pubmed, Embase, Cochrane, and Web of Science databases were searched for studies on metformin used in various experimental animal tumor models from 2008 to 2022. Meta-analysis was performed using STATA 16.0 software after screening literature extraction data and methodological quality evaluation by inclusion and exclusion criteria. A total of 24 studies with 1108 model animals were included. Meta-analysis results showed that this study used meta-analysis for quantitative synthesis of study results and found that tumor model animals of different species showed different degrees of reduction in tumor volume, weight, and number after metformin intervention.
