Higher Fat-Related Body Composition Measurement and Lower Resting-State Inter-Network Functional Connectivity of APOE ε4 Carrier in Mild Cognitive Impairment Patients With Aβ Deposition
10.47825/jkgp.2022.26.2.76
- Author:
In Hyeok CHOI
1
;
Sheng-Min WANG
;
Yoo Hyun UM
;
Hyun Kook LIM
;
Chang Uk LEE
;
Dong Woo KANG
Author Information
1. Department of Psychiatry, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
- Publication Type:Original Article
- From:Journal of Korean Geriatric Psychiatry
2022;26(2):76-83
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objective:We aimed to evaluate the impact of interaction between APOE ε4 carrier status and body composition measurements on intra- and inter-regional functional connectivity (FC) in mild cognitive impairment (MCI) patients with Aβ deposition.
Methods:MCI patients with and without APOE ε4 allele (carrier, n=86; non-carrier, n=95) underwent neuropsychological battery, resting-state functional magnetic resonance imaging scans, positron emission tomography scans with [ 18 F] flutemetamol, and bioelectri-cal impedance analysis for measuring body composition. We employed a priori defined regions of interest to investigate the intra- and inter-network FC profiles of default mode network (DMN), central executive network (CEN), and salience network (SN).
Results:There was a significant interaction of APOE ε4 carrier status with body fat mass index, visceral fat area, and waist-hip circumference ratio for inter-network FC between DMN and CEN, contributing higher fat-related body composition measurements in the APOE ε4 carrier with lower DMN-CEN FC.
Conclusion:The present results highlight the detrimental effect of APOE ε4 carrier status on the associations between the fatrelated body composition measurements and FC in the MCI patients with Aβ accumulation.
