Effect of Chinese Medicine on Pyroptosis of Autoimmune Disease： A Review
10.13422/j.cnki.syfjx.20222136
- VernacularTitle:中药对自身免疫性疾病细胞焦亡影响的研究进展
- Author:
Qiuyuan WANG
1
;
Youwen LIU
2
;
Chen YUE
2
;
Xue ZHANG
2
Author Information
1. Henan University of Chinese Medicine，Zhengzhou 450046，China
2. Luoyang Orthopedic-Traumatological Hospital of Henan Province/Henan Provincial Orthopedic Hospital，Luoyang 471000，China
- Publication Type:Journal Article
- Keywords:
Chinese medicine;
autoimmune disease;
pyroptosis;
experimental studies
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(2):260-269
- CountryChina
- Language:Chinese
-
Abstract:
Pyroptosis is a recently discovered programmed cell death mediated by cysteinyl aspartate specific proteinase （Caspase）， which may lead to the release of intracellular inflammatory substances to extracellular and induce inflammatory cascades.Autoimmune diseases （ADs） is a kind of disease in which the body's immune tolerance is impaired， and the body overproduces autoantibodies， causing damage to its tissues.The pathogenic factors of ADs are complex and the pathogenesis is still unclear. With the deepening of the research on pyroptosis， more and more results show that pyroptosis is involved in the pathogenesis of various ADs such as rheumatoid arthritis， ulcerative colitis， systemic lupus erythematosus， and psoriasis. Glucocorticoid drugs， anti-rheumatism drugs， and biological agents are mostly used in the clinical treatment of ADs， but the therapeutic effect of some drugs is limited， and there are some long-term adverse reactions. Chinese medicine in the treatment of ADs has been proven to be safe and effective in long-term clinical practice. It has the characteristics of multiple targets and few side effects and has certain advantages in controlling the course of the disease. More and more studies have found that a variety of Chinese medicine formulations， single Chinese medicine， and active ingredients of Chinese medicine treat ADs through the intervention of pyroptosis. Therefore， this paper reviewed the experimental studies on the effect of Chinese medicine on pyroptosis in ADs in recent years， hoping to provide references for clinical treatment and scientific research.
