Effect of Ferroptosis on Atherosclerosis and Chinese Medicine Intervention： A Review
10.13422/j.cnki.syfjx.20221406
- VernacularTitle:铁死亡在动脉粥样硬化中的作用及中医药干预研究进展
- Author:
Li ZHU
1
;
Hongfei WU
1
Author Information
1. School of Pharmacy，Anhui University of Chinese Medicine & Laboratory of Rearch and Development of Traditional Chinese Medicine in Anhui Province，Hefei 230012，China
- Publication Type:Journal Article
- Keywords:
ferroptosis;
atherosclerosis;
lipid peroxidation;
oxidative stress;
Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(2):244-252
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis （As） is a chronic vascular disease caused by lipid deposition on the vascular wall and is characterized by lipid metabolism disorder，oxidative stress，and inflammation. It is the pathological basis of cardiovascular and cerebrovascular diseases such as coronary heart disease，heart failure，and stroke. Ferroptosis is a new type of cell death caused by iron-dependent lipid peroxidation，which is morphologically，biologically，and genetically distinct from other types of cell death. The pathogenesis of ferroptosis is complex and is mainly related to the activity of the glutathione/glutathione peroxidase 4 antioxidant system，iron metabolism，iron autophagy，lipid peroxidation，and other pathways. Ferroptosis plays an important role in the process of As and is involved in many pathological processes such as vascular endothelial cell injury，macrophage inflammation，foam cell formation，and vascular smooth muscle cell proliferation and migration. It has become a new target for As research. Traditional Chinese medicine （TCM） is a unique and valuable medical science in China，with profound theoretical and practical accumulation. Studies have shown that Chinese medicine compounds，Chinese medicine monomers，and active ingredients can regulate ferroptosis in vascular-related cells and have unique advantages in the prevention and treatment of As. This article mainly reviewed the role of ferroptosis in various pathological links of As and related Chinese medicine intervention，aiming to provide a new direction for the prevention and treatment of As by Chinese medicine from the perspective of ferroptosis.
