Relationship between HLA-DRB1 Gene Polymorphisms and Susceptibility of Pulmonary Tuberculosis in Patients with Type 2 Diabetes Mellitus: 124 Case-control Study
10.3969/j.issn.1006-9771.2013.06.017
- VernacularTitle:HLA-DRB1基因多态性与糖尿病并发肺结核易感性的研究
- Author:
Yuhua WANG
;
Yuxun WANG
;
Yachen AN
;
Chunmei JI
;
Guorong LIU
;
Xiaojing ZHAO
;
Suling GAO
;
Jiang ZHANG
;
Yan WANG
;
Fumin FENG
- Publication Type:Journal Article
- Keywords:
tuberculosis, pulmonary, diabetes, HLA gene, polymorphism, case-control study
- From:
Chinese Journal of Rehabilitation Theory and Practice
2013;19(6):561-564
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between the HLA-DRB1 gene polymorphisms and susceptibility of pulmonary tuberculosis (TB) in patients with type 2 diabetes mellitus in North China. Methods A 1∶1 matched case-control study was adopted. Polymerase chain reaction-sequence-specific primers techniques (PCR-SSP) and restriction fragment length polymorphism (RFLP) was used to type polymorphisms (DR15, DR16, DR1, DR11). Information on environmental-related risk factors and pathological changes of tuberculosis was collected using a pre-tested standard questionnaire. Variance analysis, Chi-square, univariate and multivariate conditional Logistic analysis were conducted with SPSS 12.0 for Window. Results A sample of 124 pairs of cases and controls was studied. Univariate analysis demonstrated that DR15 mutant increased the risk of susceptibility of pulmonary tuberculosis (OR＝2.461, 95%CI: 1.363~4.444, P=0.002),and it would further increased if DR16 mutant occurred together (OR=4.904, 95%CI: 1.554~15.476). In multivariate analysis, DR15 mutant also associated with susceptibility of pulmonary tuberculosis (OR=2.996, 95%CI: 1.51~5.945). Conclusion Polymorphism of DR15 genotype might be a susceptible genotype of TB patients with type 2 diabetes mellitus in North China.
