Effect of Chinese Herbal Compounds for Tonifying Kidney and Nourishing and Activating Blood on Mitochondrial Homeostasis in Treatment of Hypovarianism Diseases： A Review
10.13422/j.cnki.syfjx.20221627
- VernacularTitle:补肾养血活血类中药复方调控线粒体稳态治疗卵巢功能减退类疾病的研究进展
- Author:
Wei SHI
1
;
Min LIU
1
;
Zhichao WANG
2
;
Keming WU
1
Author Information
1. Hospital of Chengdu University of Traditional Chinese Medicine（TCM），Chengdu 610075，China
2. Modern Research Center for TCM of Shanxi University，Taiyuan 030006，China
- Publication Type:Journal Article
- Keywords:
tonifying kidney and nourishing and activating blood;
Chinese herbal compounds;
hypovarianism diseases;
mitochondria;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(1):240-249
- CountryChina
- Language:Chinese
-
Abstract:
Hypovarianism diseases mainly include diminished ovarian reserve， premature ovarian insufficiency， and premature ovarian failure， which decreased female reproductive capacity due to various causes. Mitochondrial dysfunction in ovarian cells can interfere with the pathway of mitochondrial energy supply to germ cells and affect follicular development and egg quality. Therefore， the role of mitochondrial homeostasis in the pathogenesis of such diseases has gradually received attention. Traditional Chinese medicine （TCM） believes that the pathogenesis of hypovarianism diseases is deficiency of kidney Qi， essence and blood as well as stasis caused by deficiency. Accordingly， tonifying kidney and nourishing and activating blood is established as the fundamental treatment. In TCM， Chinese herbal compounds for tonifying kidney， replenishing essence， and nourishing and activating blood were mostly used， which can improve the secretion of ovarian hormones and ovulatory function to enhance female reproductive capacity. These compounds have definite clinical efficacy and unique advantage of treating different diseases with same method. The effect of Chinese herbal compounds for tonifying kidney and nourishing and activating blood on "Qi and blood" is closely related to mitochondrial function， and thus more and more studies have been conducted to explore the experimental mechanism of these Chinese herbal compounds in regulating mitochondrial homeostasis and protecting ovarian function. On this basis， the paper summarized and elaborated the experimental studies on the dynamic regulation of mitochondrial homeostasis in the treatment of hypovarianism diseases by Chinese herbal compounds for tonifying kidney， replenishing essence and nourishing and activating blood. Moreover， the paper reviewed the related mechanism of regulating mitochondrial homeostasis in ovarian cells， promoting follicular development， and delaying ovarian aging by Chinese herbal compounds for tonifying kidney and nourishing and activating blood through improving mitochondrial function， resisting mitochondrial oxidative stress damage as well as regulating mitochondrial quality and quantity in multi-effect and multi-target way， in order to provide a new perspective for further research on improving female fertility with Chinese medicine.
