Improvement of Diabetic Cardiomyopathy by Chinese Medicine Based on TGF-β/Smad Pathway： A Review
10.13422/j.cnki.syfjx.20221603
- VernacularTitle:中药基于TGF-β/Smad信号通路改善糖尿病心肌病的研究进展
- Author:
Peng YANG
1
;
Tonghua LIU
2
;
Lingling QIN
2
;
Lili WU
2
;
Chengfei ZHANG
2
;
Chuan PENG
3
;
Qiue ZHANG
2
Author Information
1. The First Clinical Medical College，Shaanxi University of Chinese Medicine，Xianyang 712046，China
2. Key Laboratory of Traditional Chinese Medicine（TCM） Health Science，Ministry of Education， Beijing University of Chinese Medicine，International Joint Research Center for Prevention and Treatment of Diabetes by TCM，Ministry of Science and Technology，Beijing 100029，China
3. Chengdu University of TCM，Chengdu 610075，China
- Publication Type:Review
- Keywords:
transforming growth factor-β （TGF-β）/Smad signaling pathway;
diabetic cardiomyopathy （DCM）;
Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(1):215-226
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic cardiomyopathy （DCM） is one of the most common cardiovascular lesions in diabetes mellitus. The development and progression of DCM is closely related to myocardial fibrosis， which has been shown to be an important pathological feature of DCM. Therefore， the treatment targeting myocardial fibrosis can help slow down the DCM progress. In the DCM progress， abnormal transduction of transforming growth factor-β （TGF-β）/Smad signaling pathway is an important mechanism of hyperglycemia-induced myocardial fibrosis. TGF-β is a key factor of myocardial fibrosis and is overexpressed during myocardial fibrosis in DCM， and Smad is a major effector in the downstream of TGF-β. By inducing myocardial apoptosis， TGF-β/Smad signal stimulates the overproduction of myofibroblasts， increase the deposition of extracellular matrix （ECM）， and plays a complex role in the pathogenesis of myocardial fibrosis in diabetic hearts. In recent years， Chinese medicine has played an increasingly important role in the prevention and treatment of DCM， and there has been an increase in the number of studies exploring the effects of Chinese medicine on the intervention of DN progress based on TGF-β/Smad signal. Various pharmacological studies have shown that Chinese medicine is safe and effective in the prevention and treatment of DCM， which has clear effects such as inhibiting the deposition of collagen， anti-myocardial fibrosis， improving cardiac function， and protecting myocardium， and TGF-β/Smad signaling pathway is one of the key pathways in which Chinese medicine， Chinese medicine monomers， and Chinese medicine compounds exert the myocardial protective effect in DCM. Based on this， this paper reviewed the existing pharmacological and experimental research results of Chinese medicine intervention in the TGF-β/Smad signaling pathway to treat DCM in the past decades， hoping to provide references for further in-depth research， development， and application of Chinese medicine in the treatment of DCM.
