Research progress on the roles of transforming growth factor-β in proliferative retinal diseases
10.3980/j.issn.1672-5123.2022.12.08
- VernacularTitle:TGF-β在增殖性视网膜疾病中的研究进展
- Author:
Xiao-Dong LI
1
;
Zhi-Lin LI
1
;
Hai-Yan WU
1
;
Run-Xi HE
1
;
Xue-Ni LUO
1
;
Xue-Jun XIE
1
Author Information
1. Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China; Key Laboratory of Sichuan Province Ophthalmopathy Prevention & Cure and Visual Function Protection, Chengdu 610075, Sichuan Province, China
- Publication Type:Journal Article
- Keywords:
transforming growth factor-β(TGF-β);
fibrosis;
proliferative vitreoretinopathy;
proliferative diabetic retinopathy;
neovascular age-related macular degeneration
- From:
International Eye Science
2022;22(12):1977-1981
- CountryChina
- Language:Chinese
-
Abstract:
Transforming growth factor-β(TGF-β)is a multifunctional biologic factor involved in the regulation of cell proliferation, apoptosis, differentiation, immune function and inflammatory response of the body. TGF-β signaling pathway-mediated myofibroblast transformation and overaccumulation of extracellular matrix(ECM)leads to retinal tissue contraction and impaired function. Various cytokine signals are involved in the fibrotic response in retinal tissue, but TGF-β is the most critical factor affecting the pathogenesis of retinal fibrotic disease. In terms of the eye, pathological fibrotic diseases such as corneal opacities, submacular fibrosis and proliferative retinal diseases cause visual impairment and blindness in millions of people worldwide, and this remains one of the major areas of unmet clinical need in ophthalmology. Therefore, this article focuses on the research progress related to the pathogenesis and therapeutic prospects of TGF-β in proliferative retinal diseases, with a view to provide more molecular targets for the prevention and treatment of proliferative retinal diseases and offer new ideas for the research of new drugs.
