Role of NLRP3 Inflammasome in Diabetic Wound Healing and Intervention of Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20221430
- VernacularTitle:NLRP3炎症小体在糖尿病创面愈合中的作用及中医药干预的研究进展
- Author:
Wenjing NIU
1
;
Peng LIU
1
;
Yanling GUO
1
;
Xin ZHOU
1
;
Biao XU
1
;
Jun WANG
1
Author Information
1. National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion， First Teaching Hospital of Tianjin University of Traditional Chinese Medicine （TCM）， Tianjin 300193， China
- Publication Type:Journal Article
- Keywords:
diabetic wound healing;
NOD-like receptor protein 3 （NLRP3） inflammasome;
Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(24):253-260
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic wounds are slow to heal， which poses a challenge to the medical field. Being vulnerable to infection， they are a major cause of amputation and even death and thus are costly. Chronic inflammation is an important culprit of the lingering diabetic wounds. NOD-like receptor protein 3 （NLRP3）， apoptosis associated speck-like protein （ASC）， and aspartate-specific proteasezymogen procaspase-1 （pro-Caspase-1）， constitute an intracellular protein complex called the NLRP3 inflammasome. Activated NLRP3 inflammasome can induce the release of pro-inflammatory factors interleukin（IL）-1β and IL-18 and participate in a variety of inflammatory responses. The activation of the NLRP3 inflammasome is associated with several inflammatory diseases. It has been concluded that many factors such as microcirculation disorder of diabetic wounds， accumulation of advanced glycation end products， oxidative stress injury， and long-term infiltration of macrophages can influence NLRP3 inflammasome， which induce persistent inflammation of the wounds. Therefore， solutions to the diabetic wound， such as targeting the NLRP3 inflammasome， reducing its hyperactivation， and inhibiting its overexpression， have emerged. Based on the correlation between the pathological changes of diabetic wounds and NLRP3 inflammasome， this article summarized the research on the methods of reducing NLRP3 inflammasome expression to promote the healing of diabetic wounds， such as regulating diabetic wound oxidative stress， balancing neutrophil extracellular traps （NETs） / NLRP3 inflammasome axis， inducing macrophage M2 polarization， reducing the production of advanced glycation end products， and enhancing autophagy. Moreover， the mechanisms of active constituents of Chinese medicine and compound Chinese medicine prescriptions against NLRP3 inflammasome activation were analyzed. Thereby， this paper is expected to provide new targets for diabetic wound healing and a reference for research the mechanism of Chinese medicine in anti-inflammation and promoting healing.
