Role of signal transducer and activator of transcription 1 in regulation of Treg/Th17 balance in hepatocellular carcinoma
10.3969/j.issn.1001-5256.2022.11.038
- VernacularTitle:肝细胞癌中细胞因子信号传导抑制因子1与调节性T淋巴细胞/辅助性T淋巴细胞17平衡的关系
- Author:
Rui SONG
1
;
Jing LI
2
;
Hongju YANG
1
;
Minyue LI
1
;
Jing YOU
1
Author Information
1. The NHC Key Laboratory of Drug Addiction Medicine, Department of Geriatric Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
2. School of Public Health, Kunming Medical University, Kunming 650500, China
- Publication Type:Reviews
- Keywords:
Carcinoma, Hepatocellular;
Cytokines;
Signal Transduction;
T-Lymphocytes, Regulatory;
T-Lymphocytes, Helper-Inducer
- From:
Journal of Clinical Hepatology
2022;38(11):2627-2631
- CountryChina
- Language:Chinese
-
Abstract:
The regulatory T cells (Treg) and helper T cells 17 (Th17) play an important role in regulation of the tumor microenvironment in hepatocellular carcinoma (HCC) because Treg/Th17 imbalance was associated with HCC cell invasion and progression. Moreover, the suppressor of cytokine signaling 1 (SOCS1), a negative regulator of the Janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathway, regulates Treg and Th17 proliferation and differentiation. This review summarized and discussed the recent advancement and progress in control of the Treg/Th17 balance in HCC and the immunity-related mechanisms in HCC development and progression, i.e., the SOCS1 structure and functions, SOCS1 role in regulation of Treg/Th17 balance in HCC, and future research direction of the field.
