Analysis of Safety and Efficacy of Penehyclidine Hydrochloride in Modified Electroconvulsive Therapy Under General Anesthesia
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2022.0418
- VernacularTitle:长托宁于全麻无抽搐电休克治疗中安全性及有效性的分析
- Author:
Xiao-yue LI
1
;
Xiang-yang ZANG
1
;
Jing-ping HU
1
;
Shao-li ZHOU
1
Author Information
1. Department of Anesthesiology， The Third Affiliated Hospital， Sun Yat-sen University， Guangzhou 510630， China
- Publication Type:Journal Article
- Keywords:
penehyclidine hydrochloride （PHC）;
atropine;
modified electroconvulsive therapy （MECT）;
premedication
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2022;43(4):661-666
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo compare the safety and efficacy of penehyclidine hydrochloride （PHC） and atropine in modified electroconvulsive therapy （MECT） under general anesthesia， and to provide a reference for clinical preoperative medication of MECT. MethodsA total of 104 patients treated with MECT were randomly divided into observation group and control group， with 52 cases in each group. The observation group was given PHC， the control group was given atropine before operation and other anesthesia methods were the same. The changes of hemodynamic indexes， the content of oral secretions and the occurrence of adverse reactions within 48 hours after electrotherapy were observed， monitored and recorded. ResultsSystolic blood pressure （SBP）， diastolic blood pressure （DBP）， mean arterial pressure （map） and heart rate （HR） of the two groups increased significantly after electrical stimulation （P<0.05）. There was no significant difference in hemodynamic indexes before and after drug injection in PHC group （P> 0.05）， and the HR increased significantly after drug injection in atropine group （P< 0.05）. The HR of atropine group after drug injection and electrical stimulation was significantly higher than that of PHC group （P< 0.05）， and there was no significant difference in blood pressure， the content of oral secretions and the occurrence of adverse reactions between the two groups （P > 0.05）. ConclusionCompared with atropine， the application of PHC in MECT has higher safety index， better effect of stabilizing hemodynamic indexes， and can be generalized clinically.
