Effect of Sleep Deprivation on Vestibular Function in Normal Adults -A Pilot Study
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2022.0515
- VernacularTitle:睡眠剥夺对正常成年人前庭功能影响的初步研究
- Author:
Shi-xin WU
1
;
Zhi-cheng LI
2
;
Shu-qi ZHANG
2
;
Ling-wei LI
2
;
Hui-qing WU
2
;
Xiang-li ZENG
2
Author Information
1. Department of Radiology， The Third Affiliated Hospital of Sun Yat-sen University， Guangzhou 510630，China
2. Department of Head and Neck Surgery， The Third Affiliated Hospital of Sun Yat-sen University，Guangzhou， 510630 China
- Publication Type:Journal Article
- Keywords:
sleep deprivation;
vestibular function;
vestibular evoked myogenic potentials;
video head impulse test
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2022;43(5):807-817
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the effect of sleep deprivation on vestibular function in normal adults. MethodsThe Pittsburgh sleep quality index （PSQI） and basic data were collected and recorded before the experiment. The 38 medical workers in the experimental group were examined by cervical vestibular evoked myogenic potential （cVEMP）， ocular vestibular evoked myogenic potential， （oVEMP） and video-head impulse test （vHIT） to check vestibular function after normal sleep and night shift， respectively， and the results were compared for their own control. At the same time， 20 normal adults were selected as the control group， and vestibular evoked myogenic potentials （VEMPs） were performed to check vestibular function for comparative analysis between groups. Results①The difference in PSQI scores between the 38 health workers and the control group was statistically significant （P<0.05）. The test group had 11 sleep disorders （ PSQI score >7） ； ②In the sleep deprivation state， the abnormal rate of oVEMP was higher than that of normal sleep （P = 0.02）， the abnormal rate of cVEMP tended to increase， and the rate of interaural asymmetry of cVEMP and oVEMP was higher than that of normal sleep （P < 0.05）， while no significant difference was seen in the abnormal rate of vHIT （P > 0.05）； ③Among the 38 healthcare workers， subjects prone to vestibular function abnormalities （abnormal group） had a higher number of years of service and number of night shift days per month than those without vestibular function abnormalities （normal group） （P < 0.05）. In the abnormal group， there were 5 cases of left-sided amplitude decrease （71%） and 2 cases of right-sided amplitude decrease （29%） in cVEMP； there were 13 cases of left-sided amplitude decrease （76%） and 4 cases of right-sided amplitude decrease （24%） in oVEMP； ④In the same normal sleep state， cVEMP performance in the test group showed statistically significant differences in prolonged P1 latency and interwave period compared with the control group （P < 0.05）. The oVEMP performance of the test group showed statistically significant differences （P < 0.05） in the prolongation of N1 latency and interwave period compared with the control group， manifested by the prolongation of latency and interwave period， and the remaining parameters did not show significant differences （P>0.05）. Conclusions①Sleep deprivation has potential， cumulative damage to otolithic function； ② Long working years and high number of night shifts per month are risk factors for sleep deprivation affecting individual vestibular function； ③Vestibular evoked myogenic potentiometry may serve as a screening tool to determine sleep-related vestibular impairment. The results of vestibular evoked myogenic potentials are more reliable when performed in a state of good recent sleep quality.
