Feasibility Analysis and Application of Pediatric Laparoscopy in the Fertility Preservation in Pubertal and Prepubertal Patients with Thalassemia Major
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2022.0510
- VernacularTitle:小儿腹腔镜在青春期及青春期前重型地中海贫血患儿生育力保存中的应用及可行性分析
- Author:
Pan-yu CHEN
1
;
Man-chao LI
1
;
Peng SUN
1
;
Jing-jie LI
1
;
Lu-bin YAN
2
;
Cong FANG
1
;
De-juan WANG
3
;
Xiao-yan LIANG
1
Author Information
1. Reproductive Medicine Center， The Sixth Affiliated Hospital， Sun Yat-sen University， Guangzhou 510655， China
2. Department of Pediatric Surgery， The Sixth Affiliated Hospital， Sun Yat-sen University， Guangzhou 510655， China
3. Department of Urinary Surgery， The Sixth Affiliated Hospital， Sun Yat-sen University， Guangzhou 510655， China
- Publication Type:Journal Article
- Keywords:
pediatric laparoscopy;
thalassemia major;
fertility preservation;
ovarian tissue
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2022;43(5):764-771
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveThe purpose of this study is to analyze the intraoperative and postoperative conditions of pediatric laparoscopy in fertility preservation in pubertal and prepubertal patients with β-thalassemia major （TM） and to further explore the prospects of pediatric laparoscopy in fertility preservation surgery. MethodsTotally 13 pubertal and prepubertal patients with β-TM who underwent ovarian tissue cryopreservation （OTC） combined with in vitro maturation （IVM） for fertility preservation through pediatric laparoscopic acquisition of ovarian tissue before hematopoietic stem cell transplantation were analyzed. ResultsAll 13 children underwent laparoscopic unilateral oophorectomy， with an average operative time of （58.31±20.25） minutes and an average intraoperative bleeding of （2.46±1.13） mL. All 13 children had no postoperative complications and an average hospital stay of （3.62±1.33） days. All children had ovarian tissue available for cryopreservation； the average pieces of ovarian tissue frozen was 7.77±2.31. Eleven of them also had mature oocytes available for cryopreservation； the average number of oocytes frozen was 4.92±4.27. ConclusionPediatric laparoscopic is a safe and effective fertility-preserving procedure that can be strongly promoted in pubertal and prepubertal patients with β-TM.
