Endometrial Expression of Oxytocin Receptor in Women with Repeated Implantation Failure During Implantation Window and in Normal Women During Menstrual Cycle
- VernacularTitle:反复种植失败患者子宫内膜“种植窗”时期催产素受体的表达
- Author:
Ting-ting XIA
1
;
Jie LI
2
;
Yuan ZHANG
3
;
Yu XI
4
;
Jian-ping OU
5
Author Information
1. Center for Reproductive Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; Reproductive Medical Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
2. Reproductive Medical Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China; Reproductive Medical Center, Tenth Shanghai People's Hospital, Tongji University, Shanghai 200072, China
3. Department of Obstetrics, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
4. Department of Infertility and Sexual Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
5. Center for Reproductive Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
- Publication Type:Journal Article
- Keywords:
repeated implantation failure;
oxytocin receptor;
endometrium
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2020;41(4):589-595
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the expression of endometrial oxytocin receptor(OTR) during the implantation window in women with repeated implantation failure(RIF) and its relationship with RIF, and to describe the characteristic of endometrial OTR of normal women during the menstrual cycle. 【Methods】 Immunohistochemistry and RT-PCR were performed on the endometrial tissue from early, middle, late proliferation and secretion phase of normal women, as well as middle secretion phase of women suffering from RIF to detect the endometrial OTR expression. Ten samples of the middle secretion phase and 5 samples of the other phases each of normal women were obtained. Ten samples of RIF women were obtained during the middle secretion phase. 【Results】 The OTR protein and mRNA expression of RIF patients was significantly higher than that of normal women in middle secretion phase(P < 0.05). There was cyclic expression of OTR/OTR mRNA of the endometrial tissue of normal women. 【Conclusion】 The high expression of OTR/OTR mRNA during the implantation widow might participate in the occurrence of RIF.
