Clinicopathological and radiologic features of postoperative recurrence of lung adenocarcinoma with micropapillary/solid structure
- VernacularTitle:伴微乳头/实体型结构早期肺腺癌术后复发的影像及临床病理因素分析
- Author:
Fen WANG
1
;
Tongfu YU
1
;
Mei YUAN
1
;
Hai XU
1
;
Yan ZHONG
1
;
Teng ZHANG
1
;
Jiajia ZHU
1
Author Information
1. Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, P. R. China
- Publication Type:Journal Article
- Keywords:
Micropapillary/solid pattern;
adenocarcinoma;
recurrence;
pathology;
computed tomography
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2022;29(06):693-697
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the radiological and clinicopathological factors affecting the postoperative recurrence of early lung adenocarcinoma with micropapillary/solid structure. Methods A total of 198 patients undergoing surgical resection for early stage lung adenocarcinoma in the First Affiliated Hospital of Nanjing Medical University from January 2016 to August 2019 were enrolled, including 100 males and 98 females, aged 28-82 (53.5±9.5) years. All patients were allocated to a recurrence group (n=21) and a non-recurrence group (n=177) according to postoperative recurrence status. Correlations of imaging and clinical features and clinical outcomes were analyzed to determine prognostic significance. Results The mean follow-up time was 27.0±11.2 months. There was no statistical difference in the imaging features of tumor maximum diameter in mediastinal window (P=0.014), C/T ratio (P=0.001), bronchial positive sign (P=0.015), pathological features of vascular invasion (P=0.024) and postoperative chemotherapy (P<0.001) between the two groups. In multivariate analysis, vascular invasion was the only independent prognostic factor (OR=0.146, P=0.047). Conclusion Vascular invasion is an independent risk factor for postoperative recurrence of early-stage lung adenocarcinoma with micropapillary/solid structure.
