Liver xenotransplantation techniques: Characteristics and difficulties
10.3969/j.issn.1001-5256.2022.10.002
- VernacularTitle:异种肝移植手术的特点与难点
- Author:
Xiao LI
1
;
Kaishan TAO
1
Author Information
1. Department of Hepato-Biliary Surgery and Army Institute of Organ Transplantation, Xijing Hospital, Air Force Military Medical University, Xi'an 710032, China
- Publication Type:Discussions by Experts
- Keywords:
Liver Transplantation;
Transplantation, Heterologous;
Surgical Procedures, Operative
- From:
Journal of Clinical Hepatology
2022;38(10):2206-2209
- CountryChina
- Language:Chinese
-
Abstract:
The rapid development of gene editing technology showed usefulness of pig xenotransplantation as a donor in clinical application. Clinical trials of non-human primates using pig heart and kidney were able to survive them for a long period of time, while the longest survival of xenograft liver transplantation was nearly 1 month, which could meet the conditions for entering clinical trials for human patients. However, compared with heart and kidney transplantation, only a few units in the world can carry out xenograft liver transplantation due to the high technical difficulty and difficult perioperative management. This review summarized the advancement and progress in the field and discussed the technical characteristics and difficulties, so as to provide experience and reference for the future development of clinical trials, i.e., comparison of pig and liver anatomy, animal models of xenograft liver transplantation, and characteristics and difficulties in liver xenotransplantation technique.
