Optimal Transfer Strategy for Early blastocysts in Patients without Transferable Cleavage-Stage Embryos
- VernacularTitle:卵裂期无可移植胚胎患者行囊胚培养后早期囊胚的最佳移植策略
- Author:
Shao-quan ZHAN
1
;
Han-yan LIU
1
;
Hong-zi DU
1
;
Li LI
1
;
Xiang-jin KANG
1
;
Lei LI
1
Author Information
1. Center for Reproductive Medicine， The Third Affiliated Hospital of Guangzhou Medical University//Key Laboratory for Reproductive Medicine of Guangdong Province//Key Laboratory for Major Obstetric Diseases of Guangdong Province//Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes， Guangzhou 510150， China
- Publication Type:Journal Article
- Keywords:
cleavage-stage embryo;
blastocyst culture;
early blastocyst;
vitrification;
live birth rate
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2021;42(1):117-123
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo analyze the clinical outcomes of Gardner stage I and stage Ⅱ fresh blastocysts transfer on day 5 in patients without transferable cleavage-stage embryos， so as to explore the best transfer strategy. MethodsA retrospective analysis was done on patients without transferable cleavage-stage embryos who underwent single blastocyst transfer in our IVF center from January 2014 to December 2019. Of the total of 178 cycles of fresh blastocyst transfer， 97 involved stage I and 81 stage Ⅱ. Control Group 1 included 754 cycles of fresh grade 2 cleavage-stage embryo transfer on day 3 and Control Group 2 included 144 transfer of day-6 vitrified blastocysts. Like study groups， two control groups were also single blastocyst or single embryo transfer cycles. The clinical outcomes including live birth rate， clinical pregnancy rate， early miscarriage rate and ongoing pregnancy rate， and neonatal conditions such as gestational week at delivery， neonatal weight and length were analyzed among the groups. ResultsThe live birth rate （7.22% vs. 18.83%/7.22% vs. 15.97%）， clinical pregnancy rate （11.34% vs. 25.33%/11.34% vs. 24.31%） and ongoing pregnancy rate （7.22% vs. 19.89%/7.22% vs. 15.97%） were significantly decreased in fresh stage I blastocyst transfer group than those in Control Group 1 （P < 0.01） and Control Group 2 （P < 0.05）. There was no significant difference in early miscarriage rate and neonatal conditions between fresh stage I blastocyst transfer group and Control Group 1 or between fresh stage I blastocyst transfer group and Control Group 2 （all P > 0.05）. There was no significant difference in clinical outcomes and neonatal conditions between fresh stage Ⅱ blastocyst transfer group and Control Group 1 or between fresh stage Ⅱ blastocyst transfer group and Control Group 2 （all P > 0.05）. ConclusionIn patients without transferable cleavage-stage embryos， all embryos are better to be cultured to blastocyte-stage. Higher clinical pregnancy rate and live birth rate could be achieved if stage I blastocysts on D5 is transferred in a subsequent thawed-cycles after extended culture and stage Ⅱ blastocysts on D5 is transferred in fresh cycles.
