Trends and risk factors of leukemia disease burden in China, 1990-20191
10.3969/j.issn.1006-2483.2022.05.005
- VernacularTitle:1990—2019年中国白血病疾病负担变化趋势及危险因素分析
- Author:
Jing YU
1
;
Hai-hong JIANG
1
;
Huan LIU
1
;
Ge LIU
1
;
Yong-yi BI
1
;
Na-na LIU
1
;
Yun-qin JIN
1
;
Hong WANG
1
Author Information
1. School of Public Health, Wuhan University , Wuhan , Hubie 430071, China
- Publication Type:Journal Article
- Keywords:
Leukemia;
Burden of disease;
Risk factors;
Disability adjusted life year;
AAPC
- From:
Journal of Public Health and Preventive Medicine
2022;33(5):23-28
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the trend and risk factors of leukemia disease burden in Chinese population from 1990 to 2019, and to provide new ideas for leukemia prevention. Methods The Global Burden of Disease (GBD) study data in 2019 were used for regression analysis through Joinpoint Regression Program. The leukemia incidence, mortality, disability adjusted life year (DALY), years of life lost (YLL), years lived with disability (YLD) and their corresponding age standardized rates were calculated and compared with global level and all Socio–Demographic Index (SDI) countries. Average annual percentage of change (AAPC) was calculated to reflect the trend of disease burden. The changes in disease burden attributable to each risk factor were calculated. Results From 1990 to 2019, the incidence of leukemia in China decreased from 12.06/100 000 to 10.87/100 000, the mortality decreased from 5.65/100 000 to 4.25/100 000 , and the DALY rate decreased from 328.95/100 000 to 162.36/100 000. The standardized incidence, standardized mortality and standardized DALY rates all decreased year by year, with AAPC being 0.6%, 1.8%, and 2.4%, respectively. In 2019, the disease burden of leukemia in China was higher than the global average, and the standardized DALY rate and standardized YLL rate were the highest among all SDI countries. Adolescents and children had the greatest decline in the disease burden index. Smoking was the main risk factor among the four risk factors collected, and the increase of body mass index (BMI) was also one of the important risk factors. Conclusion From 1990 to 2019, the disease burden of leukemia in China generally showed a downward trend. Smoking is the main risk factor of leukemia. At present, the disease burden of leukemia in China is still at a high level, and intervention should be strengthened for key populations.
