Role of Takeda G protein-coupled receptor-5 in non-viral liver diseases
10.3969/j.issn.1001-5256.2022.09.043
- VernacularTitle:胆汁酸G蛋白偶联受体5在非病毒性肝病中的作用
- Author:
Qun ZHOU
1
;
Hua ZHANG
2
;
Ping LIU
1
;
Jiamei CHEN
2
Author Information
1. Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine; Institute of Liver Diseases, Shanghai University of Traditional Chinese Medicine; Key Laboratory of Liver and Kidney Diseases, Ministry of Education; Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai 201203, China;Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai Frontiers Science Center of TCM Chemical Biology, Shanghai 201203, China
2. Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine; Institute of Liver Diseases, Shanghai University of Traditional Chinese Medicine; Key Laboratory of Liver and Kidney Diseases, Ministry of Education; Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai 201203, China
- Publication Type:Reviews
- Keywords:
Takeda G Protein-Coupled Receptor-5;
Non-Alcoholic Fatty Liver Disease;
Liver Diseases, Alcoholic;
Cholangitis, Sclerosing
- From:
Journal of Clinical Hepatology
2022;38(9):2172-2176
- CountryChina
- Language:Chinese
-
Abstract:
Non-viral liver diseases mainly include nonalcoholic fatty liver disease, alcoholic liver disease, autoimmune liver disease, and cholestatic liver disease, and the prevalence rate of non-viral liver diseases tends to increase in recent years. Takeda G protein-coupled receptor-5 (TGR5) belongs to the G protein-coupled receptor superfamily and is activated by primary and secondary bile acids. TGR5 plays an important regulatory role in bile acid homeostasis, basal metabolism, energy balance, and alleviation of inflammatory response and is a potential therapeutic target for many diseases. An increasing number of evidence has shown that TGR5 exerts a protective effect on the liver by improving bile acid and glycolipid metabolism in liver, alleviating liver inflammation, and reducing liver steatosis. This article reviews the recent advances in the basic research on TGR5 in the field of non-viral liver diseases, so as to facilitate the development of the research on TGR5.
