Research advances in the mechanism of abnormal bile acid metabolism caused by gene mutation
10.3969/j.issn.1001-5256.2022.09.036
- VernacularTitle:基因突变致胆汁酸代谢异常相关发生机制的研究进展
- Author:
Bo YI
1
;
Xue LI
2
;
Shanhong TANG
3
Author Information
1. Chengdu Medical College, Chengdu 610500, China;Department of Gastroenterology, The General Hospital of Western Theater Command, Chengdu 610083, China
2. Department of Gastroenterology, The General Hospital of Western Theater Command, Chengdu 610083, China;School of Medicine and Life Science, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China
3. Department of Gastroenterology, The General Hospital of Western Theater Command, Chengdu 610083, China
- Publication Type:Reviews
- Keywords:
Bile Acids and Salts;
Cholestasis;
Metabolism;
Mutation
- From:
Journal of Clinical Hepatology
2022;38(9):2136-2140
- CountryChina
- Language:Chinese
-
Abstract:
Bile acids are synthesized and catabolized by the liver, and many factors can lead to disorders in the production, secretion, and reabsorption of bile acids, thereby causing abnormal bile acid metabolism in vivo . Common predisposing factors include hepatitis, viruses, alcohol, drugs, biliary obstruction, and inheritance. It has been reported that abnormal bile acid metabolism is associated with transporter gene mutation, and in-depth studies have been conducted in China and globally. This article reviews the mechanism of abnormal bile acid metabolism caused by gene mutations and related research advances, so as to provide a new basis and new ideas for the diagnosis and treatment of such diseases.
