Concordant systemic and local eosinophilia relates to poorer disease control in patients with nasal polyps.
10.3760/cma.j.cn115330-20210428-00235
- VernacularTitle:全身性和局部性嗜酸粒细胞增多对鼻息肉治疗预后的差异影响分析
- Author:
Kang Hua WANG
1
;
Jie DENG
1
;
Meng YANG
2
;
Yang CHEN
1
;
Feng Hong CHEN
1
;
Wen Xiang GAO
1
;
Yin Yan LAI
1
;
Jian Bo SHI
1
;
Yue Qi SUN
3
Author Information
1. Otorhinolaryngology Hospital, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
2. Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
3. Department of Otorhinolaryngology, the Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China.
- Publication Type:Journal Article
- MeSH:
Chronic Disease;
Eosinophilia;
Eosinophils;
Humans;
Nasal Polyps;
Rhinitis;
Sinusitis
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2021;56(10):1042-1050
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore whether blood and polyp tissue eosinophil numbers are independent risk factors for poor disease control in patients with nasal polyp. Methods: By using the electronic medical records database and manual evaluation, 183 nasal polyp patients who had undergone endoscopic sinus surgery at least one year prior to the study with complete data of tissue specimens, baseline blood routine test, nasal endoscopy and sinus computed tomography, were identified and recruited to assess disease control based on the criteria of a European Position Paper on Rhinosinusitis and Nasal Polyps 2012 (EPOS 2012). Multiple logistic regression model was used to determine the association between blood and tissue eosinophil numbers and risk of poor disease control by adjusting for demographics and comorbidities. Results: We broke down the cohort into 4 groups according to blood (0.3×109/L) and tissue (10%) eosinophils. The patients without eosinophilic inflammation represented the largest group (41.5%). The group with concordant blood and tissue eosinophilia represented the second largest (31.2%), and the patients with isolated tissue (15.3%) or blood (12.0%) eosinophilia were relatively rare. Multiple logistic regression models found blood eosinophil count and tissue eosinophil percentage were independently associated with increased risk for poor disease control after adjustments for covariates related to poor treatment outcome. Furthermore, subjects with concordant blood and tissue eosinophilia had a higher risk for poor disease control than those with isolated blood or tissue eosinophilia. Conclusion: Concordant blood and tissue eosinophilia relates to a higher likelihood of poor disease control than isolated blood or tissue eosinophilia after adjustment of potential confounders in nasal polyp patients.
