Effect of rebamipide on the acute gouty arthritis in rats induced by monosodium urate crystals.
- Author:
Gui Hong WANG
1
;
Ting ZUO
1
;
Ran LI
1
;
Zheng Cai ZUO
1
Author Information
1. Department of Rheumatology and Immunology, Anqing Hospital of Anhui Medical University, Anqing 246000, Anhui, China.
- Publication Type:Journal Article
- Keywords:
Animal models;
Gouty arthritis;
Rats;
Rebamipide
- MeSH:
Alanine/analogs & derivatives*;
Animals;
Arthritis, Gouty/drug therapy*;
Interleukin-1beta;
Male;
Quinolones;
Rats;
Uric Acid
- From:
Journal of Peking University(Health Sciences)
2021;53(4):716-720
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the role of rebamipide in the treatment of acute gout arthritis rats induced by monosodium urate (MSU) crystal.
METHODS:Forty-two male rats were randomly divided into three groups (n=14). Group A was treated with oral rebamipide, group B with oral colchicine, and group C with oral placebo. The rats were monitored for the induction of arthritis with clinical manifestations and pathological changes, and the levels of interleukin (IL)-1β、IL-6、IL-10, and tumor necrosis factor (TNF)-α in serum were measured.
RESULTS:In group C, the clinical score and swelling index reached the maximum in 24 h, and then gradually decreased to 72 h. After 24 h of model induced, the clinical scores in group C were significantly higher than those in group A and group B [2 (1-3) vs. 0 (0-1) vs. 1 (0-2), P < 0.01], the swelling indexes in group C were significantly higher than those in group A and group B [0.36 (0.16-0.52) vs. 0.11 (0-0.20) vs. 0.12 (0-0.16), P < 0.01]. Histologically, after 24 h of model induced, there was a large number of neutrophil infiltration in the synovium of group C [scale score: 4 (2-4)], and there was no significant inflammatory cell infiltration in group A [1 (0-2)] and group B [1 (0-2)], the difference was statistically significant (P < 0.001). After 24 h of model induced, the levels of IL-1β, IL-6, IL-10, and TNF-α in serum of group C were significantly higher than those in group A and B [IL-1β: (41.86±5.72) vs. (27.35±7.47) vs. (27.76±5.28) ng/L, IL-6: (1 575.55±167.11) vs. (963.53±90.22) vs. (964.08±99.31) ng/L, IL-10: (37.96±3.76) vs. (21.68±4.83) vs. (16.20±2.49) ng/L, TNF-α: (21.32±1.34) vs. (15.82±2.54) vs. (17.35±7.47) μg/L, P < 0.001].
CONCLUSION:Rebamipide has a protective effect on acute gout arthritis rats induced by MUS crystals.
