Association between root abnormalities and related pathogenic genes in patients with generalized aggressive periodontitis.
- Author:
Jian LIU
1
;
Xian E WANG
1
;
Da LV
1
;
Min QIAO
1
;
Li ZHANG
1
;
Huan Xin MENG
1
;
Li XU
1
;
Ming Xin MAO
1
Author Information
1. Department of Periodontology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.
- Publication Type:Journal Article
- Keywords:
Aggressive periodontitis;
Gene;
Root abnormality;
Single nucleotide polymorphisms
- MeSH:
Adult;
Aggressive Periodontitis/genetics*;
Case-Control Studies;
Female;
Gene Frequency;
Genetic Predisposition to Disease;
Genotype;
Humans;
Male;
Polymorphism, Single Nucleotide;
Receptors, Calcitriol/genetics*;
Young Adult
- From:
Journal of Peking University(Health Sciences)
2020;53(1):16-23
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the association between the abnormal root morphology and bone metabolism or root development related gene polymorphism in patients with generalized aggressive periodontitis.
METHODS:In the study, 179 patients with generalized aggressive periodontitis were enrolled, with an average age of (27.23±5.19) years, male / female = 67/112. The average number of teeth remaining in the mouth was (26.80±1.84). Thirteen single nucleotide polymorphisms (SNPs) of nine genes which related to bone metabolism and root development were detected by matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS). Root abnormalities were identified using periapical radiographs. The abnormal root morphology included cone-rooted teeth, slender-root teeth, short-rooted teeth, curved-rooted teeth, syncretic-rooted molars, and molar root abnormalities. The number of teeth and incidence of abnormal root morphology in different genotypes of 13 SNPs were analyzed.
RESULTS:The constituent ratio of root with root abnormality in GAgP patients was 14.49%(695/4 798). The average number of teeth with abnormal root morphology in GAgP was (3.88±3.84). The average number of teeth with abnormal root morphology in CC, CT and TT genotypes in vitamin D receptor (VDR) rs2228570 was (4.66±4.10), (3.71±3.93) and (2.68±2.68). There was significant difference between TT genotype and CC genotype (t = 2.62, P =0.01). The average number of root morphological abnormalities in CC, CT and TT genotypes of Calcitotin Receptor (CTR) gene rs2283002 was (5.02±3.70), (3.43±3.95), and (3.05±3.12). The incidence of root morphological abnormalities in CC genotype was higher than that in the patients with CT and TT, and the difference was statistically significant(87.86% vs. 65.26% & 63.64%, P=0.006, adjusted OR =3.71, 95%CI: 1.45-9.50). There was no significant difference in the incidence of abnormal root morphology between CT and TT genotypes.
CONCLUSION:VDR rs2228570 and CTR rs2283002 may be associated with the occurrence of abnormal root morphology in patients with generalized aggressive periodontitis, which is worthy of further research.
